A second population of NPSR1-expressing principal neurons (PN) is located in the lateral nucleus of the amygdala (LA ), but the posterior regions of the basolateral nucleus and the central nucleus of the amygdala (CeA) are largely devoid of NPSR1 mRNA. Intracellularly, G αq signaling and calcium ions seem to be mandatory for the observed current and increased neuronal excitability.Īs described previously, we detected NPSR1-coding mRNA predominantly in the anterior part of the basolateral amygdala (aBA) by fluorescence in situ hybridization in mouse brain slices ( Figure 1A). Conclusion: NPSR1 activation in amygdalar neurons inhibits voltage-gated potassium (K +) channels, most likely members of the delayed rectifier family. Intracellular tetraethylammonium or 4-aminopyridine reduced the NPS-evoked current. GDP-β-S and BAPTA, but neither adenylyl cyclase inhibition nor 8-Br-cAMP, abolished the current. The NPSR1-mediated current had a reversal potential near the potassium reversal potential (E K) and was accompanied by an increase in membrane input resistance. Results: Application of NPS reliably evokes inward-directed currents in amygdalar neurons recorded in brain slice preparations of male and female mice. We used pharmacological interventions to characterize the NPSR1-mediated current induced by NPS application. Methods: To elucidate possible G-protein-dependent signaling and effector systems, we performed whole-cell patch-clamp recordings on principal neurons of the anterior basolateral amygdala of mice. Although there is a lot of data retrieved from behavioral studies using pharmacology or genetic interventions, little is known about intracellular signaling cascades in neurons endogenously expressing the NPSR1. Please email for more information.Background: The neuropeptide S system, consisting of the 20 amino acid neuropeptide NPS and its G-protein-coupled receptor (GPCR) neuropeptide S receptor 1 (NPSR1), has been studied intensively in rodents. Institutional/libary rates available on a case-by-case basis. Yes, group rates are available for group sizes of 3 people and up. Please visit this page to see our subscription rates. How much does a subscription to WYDaily cost?
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